Development of a bedrest muscle stress apparatus

In attempting further to define the deleterious effects of spaceflight on the human body, measurement systems and techniques were devised to determine the loss of skeletal muscle strength and tone as a result of spaceflight exposure. In order to determine how the muscle degradation process progresses with time during nonuse, a system for measuring muscle stress during bedrest was developed. The Bedrest Muscle Stress Apparatus is configured to slip snugly over the foot board of a standard hospital bed. Data collected with this device correlated well with pre- and post-bedrest data collected with the original skeletal muscle stress apparatus

Looking to the Future of Wildlife Conservation: Durable Wildlife Policy for the 21st Century

Wildlife conservation in the United States was built by the dollars of consumptive users. Monies from the sale of hunting licenses, as well as excise taxes on firearms, ammunition, and archery tackle through the Pittman-Robertson Federal Aid in Wildlife Restoration Act (PR), currently fuel a complex system of wildlife conservation via multiple levels of government. However, the number of hunters in this country is rapidly declining, the sale of firearms and ammunition is increasingly unrelated to hunting, and contemporary consumers tend to express different values than traditional hunters. These changes pose significant challenges of relevancy and funding to state and federal fish and wildlife agencies charged with wildlife management and conservation. This thesis seeks to contribute to three topics that are relevant to the future of the field of wildlife conservation by clarifying commonly used – but rarely defined – language, analyzing state-specific responses to declines in funding for conservation, and analyzing concerns regarding the North American Model of Wildlife Conservation. The first chapter of this thesis aims to clarify terms commonly used in scholarship related to the take of wildlife to facilitate clear communication. When definitions vary among practitioners and academics, misunderstandings and breakdowns in communication arise. Reconciling distinctions between legal and social licensure facilitates more accurate depictions of take. The second chapter catalogues and analyzes dedicated revenue generated for state wildlife agencies via 25 distinct mechanisms and sought to identify factors which influence intrastate diversity in dedicated revenue. The third chapter examines a growing body of literature regarding the North American Model of Wildlife Conservation and finds significant variation in critiques of this concept. I address these concerns in the historical context of the model. In short, this thesis addresses wildlife communication, the funding model of wildlife conservation, and a model which describes one interpretation of the laws and policies which differentiate wildlife conservation in the United States and Canada from the rest of the world. It is my hope that this work will be of some use to those who seek to conserve wildlife and wild places for future generations

Big five personality characteristics and commitment levels in romantic relationships

While numerous empirical studies have looked at commitment levels across various aspects of life, little research has attempted to integrate these disparate literatures. Accordingly, this study attempts to address this gap by adapting a taxonomy of commitment commonly used in the workplace to the analysis of commitment in romantic relationships. Additionally, the relationship between personality and levels of commitment in romantic relationships were investigated utilizing the Big Five personality factors. Results indicated that personality does relate to commitment and that the affective (emotional) and continuance (economic) facets of commitment have specific relevance to understanding commitment expressed in romantic relationships. Gender similarities and differences, as well as directions for future research, are discussed

Electrokinetic removal of uranium from contaminated, unsaturated soils

Electrokinetic remediation of uranium-contaminated soil was studied in a series of laboratory-scale experiments in test cells with identical geometry using quartz sand at approximately 10 percent moisture content. Uranium, when present in the soil system as an anionic complex, could be migrated through unsaturated soil using electrokinetics. The distance that the uranium migrated in the test cell was dependent upon the initial molar ratio of citrate to uranium used. Over 50 percent of the uranium was recovered from the test cells using the citrate and carbonate complexing agents over of period of 15 days. Soil analyses showed that the uranium remaining in the test cells had been mobilized and ultimately would have been extracted. Uranium extraction exceeded 90 percent in an experiment that was operated for 37 days. Over 70 percent of the uranium was removed from a Hanford waste sample over a 55 day operating period. Citrate and carbonate ligand utilization ratios required for removing 50 percent of the uranium from the uranium-contaminated sand systems were approximately 230 moles ligand per mole uranium and 1320 moles ligand per mole uranium for the waste. Modifying the operating conditions to increasing the residence time of the complexants is expected to improved the utilization efficiency of the complexing agent

Fission yeast 26S proteasome mutants are multi-drug resistant due to stabilization of the pap1 transcription factor

Here we report the result of a genetic screen for mutants resistant to the microtubule poison methyl benzimidazol-2-yl carbamate (MBC) that were also temperature sensitive for growth. In total the isolated mutants were distributed in ten complementation groups. Cloning experiments revealed that most of the mutants were in essential genes encoding various 26S proteasome subunits. We found that the proteasome mutants are multi-drug resistant due to stabilization of the stress-activated transcription factor Pap1. We show that the ubiquitylation and ultimately the degradation of Pap1 depend on the Rhp6/Ubc2 E2 ubiquitin conjugating enzyme and the Ubr1 E3 ubiquitin-protein ligase. Accordingly, mutants lacking Rhp6 or Ubr1 display drug-resistant phenotypes

From START to FINISH : the influence of osmotic stress on the cell cycle

Peer reviewedPublisher PD

How to design a complex behaviour change intervention: experiences from a nutrition-sensitive agriculture trial in rural India

Many public health interventions aim to promote healthful behaviours, with varying degrees of success. With a lack of existing empirical evidence on the optimal number or combination of behaviours to promote to achieve a given health outcome, a key challenge in intervention design lies in deciding what behaviours to prioritise, and how best to promote them. We describe how key behaviours were selected and promoted within a multisectoral nutrition-sensitive agriculture intervention that aimed to address maternal and child undernutrition in rural India. First, we formulated a Theory of Change, which outlined our hypothesised impact pathways. To do this, we used the following inputs: existing conceptual frameworks, published empirical evidence, a feasibility study, formative research and the intervention team’s local knowledge. Then, we selected specific behaviours to address within each impact pathway, based on our formative research, behaviour change models, local knowledge and community feedback. As the intervention progressed, we mapped each of the behaviours against our impact pathways and the transtheoretical model of behaviour change, to monitor the balance of behaviours across pathways and along stages of behaviour change. By collectively agreeing on definitions of complex concepts and hypothesised impact pathways, implementing partners were able to communicate clearly between each other and with intervention participants. Our intervention was iteratively informed by continuous review, by monitoring implementation against targets and by integrating community feedback. Impact and process evaluations will reveal whether these approaches are effective for improving maternal and child nutrition, and what the effects are on each hypothesised impact pathway

December 1965

Massachusetts Turf and Lawn Grass Council Better Turf Through Research and Educatio

Translating global recommendations on HIV and infant feeding to the local context: the development of culturally sensitive counselling tools in the Kilimanjaro Region, Tanzania

BACKGROUND: This paper describes the process used to develop an integrated set of culturally sensitive, evidence-based counselling tools (job aids) by using qualitative participatory research. The aim of the intervention was to contribute to improving infant feeding counselling services for HIV positive women in the Kilimanjaro Region of Tanzania. METHODS: Formative research using a combination of qualitative methods preceded the development of the intervention and mapped existing practices, perceptions and attitudes towards HIV and infant feeding (HIV/IF) among mothers, counsellors and community members. Intervention Mapping (IM) protocol guided the development of the overall intervention strategy. Theories of behaviour change, a review of the international HIV/IF guidelines and formative research findings contributed to the definition of performance and learning objectives. Key communication messages and colourful graphic illustrations related to infant feeding in the context of HIV were then developed and/or adapted from existing generic materials. Draft materials were field tested with intended audiences and subjected to stakeholder technical review. RESULTS: An integrated set of infant feeding counselling tools, referred to as 'job aids', was developed and included brochures on feeding methods that were found to be socially and culturally acceptable, a Question and Answer Guide for counsellors, a counselling card on the risk of transmission of HIV, and an infant feeding toolbox for demonstration. Each brochure describes the steps to ensure safer infant feeding using simple language and images based on local ideas and resources. The brochures are meant to serve as both a reference material during infant feeding counselling in the ongoing prevention of mother to child transmission (pMTCT) of HIV programme and as take home material for the mother. CONCLUSION: The study underscores the importance of formative research and a systematic theory based approach to developing an intervention aimed at improving counselling and changing customary feeding practices. The identification of perceived barriers and facilitators for change contributed to developing the key counselling messages and graphics, reflecting the socio-economic reality, cultural beliefs and norms of mothers and their significant others